Stands for Anti-Neutrophil Cytoplasm Antibody.
A type of blood test used to detect the presence and level of ANCA within your blood.
A condition where there are too few healthy red blood cells to carry the normal amount of oxygen to the body’s tissues, leading to feelings of tiredness and/or weakness.
A protein produced by plasma cells that the immune system generates to respond to a specific antigen.
A substance that the immune system perceives as ‘foreign’ or dangerous. The body responds to antigens by producing antibodies.
A type of antibody produced by the immune system that binds to one of the body’s own proteins instead of a foreign object, leading to autoimmune diseases.
Occurs when the disease is caused by the body’s own immune system. This autoimmune reaction (or ‘attack’) triggers the development of the disease.
In a biopsy, a small sample of tissue is removed from the body so it can be examined under a microscope.
A side effect of some medicines that means fewer blood cells are produced in the bone marrow than usual.
C5a A protein within the complement system that plays a key part in AAV-related inflammation.
The original name for Eosinophilic Granulomatosis with Polyangiitis, please see ‘EGPA’ for full description.
The mental processes involved in thinking clearly and understanding information.
Other diseases that you may well have as well as AAV, such as diabetes or asthma.
Proteins including C5a that form part of the immune system, increasing the body’s ability to fight infection, but can lead to unwanted inflammation in people with AAV.
A medicine used to control autoimmune diseases like AAV by suppressing the immune system’s response.
Eosinophilic Granulomatosis with Polyangiitis, previously called Churg-Strauss syndrome, a type of AAV that often affects the lungs and/or sinuses
A type of white blood cell that helps the body’s allergic responses.
Extreme tiredness and exhaustion that doesn’t always go away with rest or sleep and may affect people physically and emotionally.
A sudden and quick change/worsening of AAV symptoms.
Granulomatosis with Polyangiitis, previously called Wegener’s, a type of AAV that usually begins in the nose, ears, eyes or mouth
The physical characteristics that a person inherits from their parents.
Networks of small blood vessels that filter blood within the kidney.
Steroid hormones that are used to treat diseases caused by an overactive immune system.
The small, nodule-like groups of cells which commonly form in GPA patients’ sinuses and lungs.
In medicine, imaging is a technique which allows healthcare professionals to look inside the patient’s body, helping them diagnose and treat disease by revealing internal structures that would otherwise be hidden by skin and bones.
The organs and processes within the body that enable it to respond to and fight infection and toxins.
A type of medicine that reduces or prevents activity within the immune system.
The use of immunosuppressants to control a patient’s immune system response.
The first treatment in AAV used to get remission.
A medical procedure that involves testing a sample of blood, urine, or other substance from the body.
A condition where someone has a reduced the number of white blood cells, putting them at greater risk of infection.
Microscopic Polyangiitis, a type of AAV that typically affects the kidney
Short for myeloperoxidase, this protein is one of the two proteins that an ANCA is formed against.
An immunosuppressant that is used to treat AAV and a number of other conditions.
Relating to small (micro) organisms, especially disease-causing bacteria.
Monoclonal means all of the same type, so each monoclonal antibody (or MAB) reacts to a single antigen. MABs are made in a laboratory.
Another immunosuppressant that is used to treat AAV as well as various other conditions.
Having an unusually low number of neutrophils in your blood.
A type of white blood cell that protects the body from infections, among other functions.
A condition that makes bones more fragile, increasing the risk of a broken bone, and can occur following prolonged use of steroids.
Short for proteinase 3, this protein is one of the two proteins that an ANCA is formed against.
A record to help doctors understand your pain. Each time you feel pain, note down how bad it is (from 1-10), what it feels like, where it is, how long it lasts, what medication you took and whether anything made it feel better or worse.
A type of white blood cell which produces a single type of antibody.
Also known as plasmapheresis, this involves plasma being removed from the blood and replaced with new plasma fluid through a specially designed machine.
A progressive disease is one that gradually becomes more severe over a period of time.
Bleeding from inside the airways in the lung. The condition requires immediate treatment.
A disease that affects fewer than 1 in 2000 people
The treatment given after a condition has not responded to previous treatments. Refractory treatment will usually involve experts reviewing your diagnosis and deciding whether to optimise your existing treatment or considering other drugs.
Refers to disease that was previously well-controlled with or without treatment, but has become active again.
A reduction in the severity of disease. Remission can be full (meaning that no activity is currently occurring as a result of active disease) or partial (meaning that disease activity has been reduced).
A disease with a remitting course is one where a patient is able to achieve remission.
The parts of the mouth, nose, throat and lungs through which air passes when people breathe.
A type of monoclonal antibody used to treat AAV and other diseases.
A form of hearing loss that reduces the ability to hear quiet sounds, and impacts the quality of sound people hear
A condition where someone has a low blood platelet count, meaning that it is more difficult for their blood to clot.
The vascular system, also called the circulatory system, is made up of the vessels that carry blood and lymph (a fluid containing white blood cells) around the body.
The original name for Granulomatosis with Polyangiitis, please see ‘GPA’ for full description.
A type of imaging procedure where high-energy rays are used to create a picture of an area inside the body.